SVEDBERG 7.0.2

SVEDBERG 7.0.2

License:Shareware

Price:$500.00

Size:8.6 MB

Date Added:07 May, 2013

Author: John Philo

Category: Multimedia & Graphics  >  CAD


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SVEDBERG is a Windows program for whole-boundary analysis of sedimentation velocity data. It fits directly to the raw scans (usually spanning the entire run) to derive the sedimentation coefficient and molar mass (or, if you prefer, sedimentation coefficient and diffusion coefficient) for up to 6 independent species (mixtures of up to 6 components).

The program is designed to be easy to use, even for novices, yet it also offers many options for the 'power user' when they are needed. It uses multi-page analysis 'documents' and a familiar user interface with toolbars and buttons, making it similar to other Windows programs to reduce the learning curve. It also incorporates a number of intelligent 'wizards' that automatically accomplish tasks such as locating the meniscus position, removal of systematic noise ("jitter") and fringe jumps from interference scans, and even making reasonable initial guesses for the molecular parameters.

This is not a package that tries to do everything---its purpose is to implement one particular approach (analysis of single species and mixtures), do that very well and very easily, and do it in a highly reproducible and well-documented manner. It is not intended to be able to handle samples where the data is strongly influenced by dynamic reversible-association reactions (interacting boundaries). However when reversible interactions are strong enough that a reversible oligomer or complex can be treated as a single species then SVEDBERG is quite useful for identifying the molar mass (stoichiometry) of that species, which in turn can be a very useful input to analysis of data using other software acquired under conditions where the dynamic interactions are more significant.

The success of this approach is demonstrated by its use in 140+ known publications. More significantly, many of these are from intermittent or casual users of AUC, proving you don't have to devote years to learning data analysis to successfully answer important research questions with SV.

The program is distributed as "trial-ware"; it can be downloaded for a 60-day free trial period.

Major features:

- Modern multi-document, Explorer-style user interface
toolbar with standard buttons for file open, file save, etc.
multiple analyses can be open simultaneously,
Explorer-like navigation tree to move to specific analysis pages (analysis steps) and between analysis documents
click-and-drag setting of meniscus marker, data limits, cell base position, etc. [see image below

Allows direct conversion of a c(s) distribution from SEDFIT into an equivalent mixture model, allowing determination of true confidence intervals for all the species fractions and sedimentation coefficients simultaneously
when desired you can modify the constant f/f0 ratio constraints (for example using oligomer constraints instead) or try removing the constraint altogether to see whether the mass of a minor component can be determined independently
SVEDBERG can load the data range and other parameters used in the c(s) fit
Allows use of any of the current methods for handling systematic noise in the raw scans:
either fitting the TIN (time-invariant noise), scan differencing, or a simple baseline offset
for interference or pseudo-absorbance scans, either arithmetic removal of "jitter" (radially-invariant noise, RIN) at a fixed region of the cell or fitting of the RIN
Improved Lamm equation solution gives s, D, and M values for each species with theoretical accuracy of better than 0.1%, and will work for small peptides
Evaluates fitted parameter confidence intervals using any of three orthogonal approaches: F statistics, the bootstrap method, or the Monte Carlo method
For multi-species fits you can choose whether to fit the total concentration and species fractions, or to fit the loading concentration for each species
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Release notes: New Release
bug fixes:
TE fixed problem with memory allocation causing false 'out of memory' errors
TE the F1 key was not bringing up context-sensitive Help
TE fixed problem with fit report formatting when using non-English regional number formatting settings
TE importing a c(s) distribution was not turning off delta-c mode if that was previously turned on
TE after switching to delta-c mode, if a fitted TIN had previously been computed it was still shown on the graphs
TE the sloping plateau parameter was incorrectly available as a fitting parameter for interference and fluorescence scans
TE line residual plots were displaying legends when legends should be off by default
TE when RIN is used the fit report now correctly shows RIN values for each scan (or tge sum of RIN + jitter when both are used)
[ SVEDBERG full changelog ]

Systems: Windows 7, Win95, Win98, WinME, WinXP, Windows 2000, Windows Vista, Windows2003

Tags: sedimentation rate calculator   analyze sedimentation rate   molecular mass calculator   sedimentation   sediment   calculate  

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